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⚠️ FOR RESEARCH PURPOSES ONLY — This compound is not FDA approved. All data presented is from clinical trials for educational reference.

MOTS-C

  • Third Party Tested
  • COA Available

Price range: $40.00 through $640.00

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a unique mitochondrial-derived peptide that functions as a systemic signaling molecule. In research settings, it is primarily studied for its role in metabolic homeostasis and its ability to regulate the AICAR-AMPK pathway. MOTS-c is unique because it is encoded in the mitochondrial DNA rather than the nuclear DNA. Research indicates that it targets skeletal muscle to enhance glucose metabolism and increase fatty acid oxidation. It is widely utilized in studies involving aging, obesity, and physical performance, as it appears to mimic many of the physiological benefits of exercise at a cellular level. This high-purity lyophilized reagent provides a consistent standard for exploring mitochondrial-to-nuclear communication.

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SKU MS10-2122 Category

Certificate of Analysis

Third Party Tested by Freedom Diagnostics

  • Latest

99.83%

Purity
Variant MOTS-c – 40mg
Lot # MS40-09
Labeled 40mg
Actual 42.21mg
Tested Aug 18, 2026

99.86%

Purity
Variant MOTS-C
Lot # MS40-08
Labeled 40mg
Actual 41.28mg
Tested Jun 28, 2026

N/A%

Purity
Variant MOTS-C 30mg
Lot # MTC-LD-01
Labeled 30mg
Actual 30mg
Tested Jun 12, 2026

99.04%

Purity
Variant MOTS-C 40mg
Lot # MTS40-07
Labeled 40mg
Actual 41.39mg
Tested May 23, 2026

Compound Information

Technical specifications

  • Molecular Profile

What Is MOTS-C?

Type 1627580-64-6
CAS Number 1627580-64-6
Molecular Weight 2174.6 g/mol
Molecular Weight (Cu) N/A
Amino Acids 16 Amino Acids
Sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Met-Cys-Ser-Ser-Leu-Glu
Formula C101H152N28O22S2
  • Storage Requirements

Stability Information

  • Store at a stable temperature and minimize warming/cooling cycles.
  • Lyophilized powder; keep sealed, dry, and protected from light.
  • After reconstitution, avoid repeated freeze–thaw cycles.

Lyophilized Powder

-20°C

Reconstituted

2-8°C

About MOTS-C

Information

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a unique mitochondrial-derived peptide that functions as a systemic signaling molecule. In research settings, it is primarily studied for its role in metabolic homeostasis and its ability to regulate the AICAR-AMPK pathway. MOTS-c is unique because it is encoded in the mitochondrial DNA rather than the nuclear DNA. Research indicates that it targets skeletal muscle to enhance glucose metabolism and increase fatty acid oxidation. It is widely utilized in studies involving aging, obesity, and physical performance, as it appears to mimic many of the physiological benefits of exercise at a cellular level. This high-purity lyophilized reagent provides a consistent standard for exploring mitochondrial-to-nuclear communication.

Product

Specifications

Molecular Formula C101H152N28O22S2
Molecular Weight 2174.6 g/mol
Sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Purity ≥99% (HPLC verified)
Form Lyophilized powder
Appearance White to off-white powder
Solubility Soluble in water, bacteriostatic water
Storage -20°C (lyophilized), 2-8°C (reconstituted)

FAQ

Frequently asked questions

What makes MOTS-c unique among peptides?
Unlike most peptides encoded in the cell’s nucleus, MOTS-c is encoded within the mitochondrial genome, acting as a “mitochondrial hormone.”
It is researched for its ability to target the skeletal muscle and increase glucose uptake, effectively mimicking the effects of exercise.

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